miRNA function in epigenetics system Aberrant epigenetics mechanism in diseases especially cancer Targeting epigenetic system using chemical drugs, miRNAs and the dcas9-Crysper system How to find CpG Islands, DNA bisulfite conversion and designing specific methylation primer miRNAs target prediction tools and how to use miRNAs with a therapeutic approach How to design gRNA for epigenetic targeting using dcas9-CRYSPR